Moldinspector.com Online Since 1999
 
Do-It-Yourself Blog for Mold Health &Mold Inspection, Testing, Removal, & Prevention, Plus Air Duct Cleaning & Building Decontamination by EnviroFry for Homes, Workplaces, & Commercial Buildings Nationwide USA, Canada, Europe, Middle East, Asia, Australia/N.Z., South America, and Worldwide!
 
 
Mold Expert Consultant  What Is Mold?  Mold Health  Mold News Mold Legal Liability Mold Inspection 
 Mold Inspector Directory  Mold Lab Analysis Mold Removal  Mold Products  Air Conditioning Mold  Workplace Mold  
 Mold Prevention  Mold Real Estate Problems  Mold Inspection Clause  Top 10 Mold Mistakes 
10 Steps To Find Hidden Mold 
 
10 Mold Inspection Steps 10 Steps Prevent Mold Legal Problems  Mold Q & A  Vehicle Detoxification  Mold Inspector Training
 
 
Contact Mold Expert Phillip Fry phil@moldinspector.com  Phone Phillip Toll-Free 1-866-300-1616 or 1-810-639-0523
or cell phone 1-480-310-7970      
Visit the Site Map at the bottom of this page.

For mold inspection, building mold inspection, mold inspector directory, mold remediation, and mold prevention for your real estate property anywhere in USA, Canada, Asia, Europe, or worldwide, please contact mold consultants Phillip Fry and Divine Fry by email phil@moldinspector.com or by phone Phillip Toll-Free 1-866-300-1616 USA and Canada, or Phil's cell # 1-480-310-7970.

 

Western USA Mold Inspection Websites
 
Arizona Mold Inspection
 
Las Vegas Mold Inspection
 
Los Angeles Mold Inspection
 
Mesa Mold Inspection
 
Orange County Mold
 Palm Springs Mold Inspection
 
Phoenix Mold Inspection
 
Sacramento Mold Inspection
 
San Diego Mold Inspection
 
San Francisco Mold Inspection
 
San Jose Mold Inspection
 
Santa Barbara Mold Inspection
 
Scottsdale Mold Inspection
 
Tucson Mold Inspector
 
Victorville Mold Inspection
 

Chronic Sinusitis Sufferers Have
Enhanced Immune Responses To Fungi

October 8, 2004 -- Scientists supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have discovered that people with chronic sinus inflammation have an exaggerated immune response to common airborne fungi. The results of their study appear online today in The Journal of Allergy and Clinical Immunology.

"This study is the first to show a possible immunologic basis for chronic sinusitis, an important starting point to better understand the etiology of the illness," says Marshall Plaut, M.D., chief of NIAID's allergic mechanisms section. Despite the enormous health impact of chronic sinusitis--nearly 30 million people were diagnosed with sinusitis in 2002, according to U.S. Centers for Disease Control and Prevention, and direct costs of the illness exceed $5.6 billion per year--the condition is very poorly understood, he says.
 
The researchers, led by Hirohito Kita, M.D., of the Mayo Clinic in Rochester , MN , compared blood samples taken from 18 people diagnosed with chronic sinusitis with blood samples from 15 healthy volunteers. Nasal secretions from the two groups were also examined for the presence of fungal proteins and inflammation-causing immune system molecules.
Airborne microscopic fungi spores abound indoors and out. People may inhale a million or more fungal spores each day, notes Dr. Kita. The mere presence of such fungi in the airways, however, is not enough to cause sinusitis because these spores can be found in the upper respiratory tracts of both sinusitis sufferers and non-sufferers. Indeed, in this study, levels of fungal proteins in nasal secretions were similar in both groups.
 
The Mayo Clinic scientists looked for evidence that people with sinusitis respond abnormally to these harmless fungi. The investigators exposed immune cells derived from the blood samples to extracts of four common airborne fungi: Alternaria, Aspergillus, Penicillium and Cladosporium. The cells of chronic sinusitis sufferers released significant amounts of three immune-modulating chemicals, called cytokines, specifically interferon-gamma, interleukin-5 (IL-5) and IL-13. In contrast, cells from healthy volunteers released very little interferon-gamma and no IL-5 or IL-13. The most dramatic responses occurred after exposure to Alternaria.
 
Importantly, says Dr. Kita, the released cytokines represent both major classes of cytokines--interferon-gamma is in the Th1 group and IL-5 and IL-13 are in the Th2 class. This is notable because scientists have thought that allergic reactions involve only Th2 cytokines, Dr. Kita explains. (While chronic sinusitis is not considered to be an allergic disease, people with the condition also often have asthma and allergic rhinitis, giving scientists reason to suspect a link.) The current findings add to an evolving understanding of allergic diseases that suggests symptoms may stem from a combination of Th1 and Th2 cytokines.
 
The combined effect of excess Th2 and Th1 cytokines released in the presence of fungi may explain a number of chronic sinusitis symptoms, including persistent inflammation of sinus and nasal mucous passages, say the scientists.
 
Previously, Mayo clinic scientists used intranasal antifungal agents to successfully treat patients with chronic sinusitis. While those studies generated controversy, in part because other researchers were unable to replicate the findings, Dr. Kita says today's report supports the rationale of treating chronic sinusitis with antifungals. Clinical trials to further test antifungal therapy for chronic sinusitis are being planned, adds Dr. Kita.
###
NIAID is a component of the National Institutes of Health, an agency of the U.S. Department of Health and Human Services. NIAID supports basic and applied research to prevent, diagnose and treat infectious diseases such as HIV/AIDS and other sexually transmitted infections, influenza, tuberculosis, malaria and illness from potential agents of bioterrorism. NIAID also supports research on transplantation and immune-related illnesses, including autoimmune disorders, asthma and allergies.
Reference: S-H Shin et al. Chronic rhinosinusitis: An enhanced immune response to ubiquitous airborne fungi. The Journal of Allergy and Clinical Immunology. Published online Oct. 8, 2004 . doi: 10.1016/j.jaci.2004.06.012.

[Home] [Masonry-Mold] [Katrina-Mold-Study] [Fraudulent-Mold-Health-Study] [Apartment-Toxic-Mold] [Ozone-Air-Purifiers] [Mold-Odor-Asthma] [Mold-Mushroom-Photo] [Mold-Sinus-Problems] [Dampness-Mold-Health] [Environmental-Mold-Home-Study] [Chronic-Sinusitis-Mold-Problem] [Alzheimer's & Mold] [Mold-Death] [Asthma & Mold] [Blood Testing] [Mold Headache] [Mold & Landscaping] [Household-Mold-Dangers] [Top-100-Mold-Health-Signs-&-Symptoms] [Mold-Health-Issues] [Scope-Of-Mold-Problem] [Mold Scientist] [Skin Diseases] [Stachybotrys Information] [Mold-Desert] [Cold-or-Allergies] [Mold-Health-Effects] [Mold-Health-Questions] [Tsunami-Deadly-Fungal-Infection] [Mold-Birth-Defects] [Ten-Health-Symptoms] [Seasonal-Allergies] [Mold-Respiratory-Hazards] [Mold-Pregnancy] [Sinusitis-Mold-Growth] [Lung-Cancer-Mold] [Asthma-Mold] [Pet-Mold-Problem] [German-Mold-Research] [Fungal-Eye-Infection] [Mold-Causes-Depression] [Asthma-Cats-Alternia-Mold] [Fungal-Research] [Neuropsychological-Mold-Link] [Tornado Mold] [Tropical Mold Infections] [Sink Mold Sickness] [Soda Pop from Aspergillus] [Aspergillosis Misdiagnosed as TB] [Fungal Infection Mimics Cancer]

Certified Environmental Hygienists  ►Ozone Kills Mold  
Ozone Odor Control  ►Carpet Deodorizer  ►Mold Expert Consultants